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Griffonia simplicifolia


Serotonin deficiency, anxiety, depression, migraines, sleeping disorders, panic attacks, aggressive behaviour ...


Composition :
50% Griffonia simplicifolia semen (with 62.5mg 5-HTP) + 50% Phaseolus vulgaris - 500 mg

Part used :

Griffonia (Griffonia simplicifolia), a woody, climbing shrub native to West and Central Africa, is a member of the pea family (Fabacea) of the genus Griffonia. It grows to about 3 meters (10ft) and bears greenish flowers followed by black pods.

The seeds of the plant contain up to 20% of 5-HTP (5-hydroxytryptophan), a metabolite of tryptophan (a essential amino acid which the body can not produce, and a important building block for the human body to form serotonin. Serotonin plays a critical role as a neurotransmitter to transport signals between neurons in the nervous system). With young adults, the liver produces 5-HTP from tryptophan, by way of the enzyme tryptophan- hydroxylase. This process is reduced in many people (stress, age) – the regular use of a 5-HTP supplement becomes thus critical. Significant levels of 5-http are also found in bananas and chocolate.

Serotonin deficiency promotes desire for chocolate; in obese patients, serotonin deficiency may cause eating binges (adephagia; especially for carbohydrates). Multiple studies about the role of 5-HTP in obese patients confirm its appetite-reducing effect. Serotonin deficiency may also cause depression, anxiety and aggressive behaviour and may be a co-factor in stress symptoms, substance abuse, thoughts of suicide, PMS (premenstrual syndrome), obesity and migraine. Serotonin regulates sleep, appetite, memory function and mental activity.

But there is still more: in the general cardiovascular system, serotonin regulates blood pressure and the contraction of the arteries. In skeletal muscles, serotonin regulates the expansion of the blood vessels (vasodilation). Serotonin levels in fybromyalgia patients (Fybromyalgia is a complex syndrom with a multitude of symptoms, like muscle pain, fatigue, fever, sleep disorders, irritable bowel and swollen lymph nodes.) are typically low. Finally, there are a number of drugs (e.g. appetite inhibiting, cholesterin reducing drugs) which cause serotonin deficiency.

Use of Griffonia can be beneficial in many of these cases, as was demonstrated in multiple studies: the supply of 5-HTP, a precursor for serotonin, significantly increases serotonin levels, while the supply of tryptophan does not show much impact (supplying serotonin is not a option, as it disintegrates before having any impact). Studies also show that in many cases (e.g. in patients suffering from depression and/or anxiety), supplying 5-HTP is more beneficial than the use of pharmaceuticals typically indicated in such cases. A clinical trial in Norway produced better results for 5-http in patients suffering from sleep disorders; clinical trials in Spain and Italy produced better results for 5-http in patients suffering from migraine.

The interest of the pharmaceutical industry in 5-HTP is limited, however, as it can not be patented.

Note: Do not take Griffonia in combination with psycho-pharmaceutical drugs (beta-blockers) such as Marplan, Cenemet, Eldepryl (Parkinson’s Disease)) or Zibralex. Do not take Griffonia when pregnant or planing on pregnancy (no studies are available at this time). Side effects with Griffonia are not known; if you need to take psycho-pharmaceutical drugs, consult with your physician about combining Griffonia. In rare cases, light nausea may occur in the beginning.


Take 2 capsules 3 times daily, with plenty of water (short term);
or 1 capsule 2 times daily, with plenty of water (long term).